Synthesis of paricalcitol: A novel strategy combining chemical and microbial transformations
作者: J. Q. LuoF. JiangW. Q. SongW. Z. FangQ. Lu
作者单位: 1Southwest Jiaotong University
刊名: Russian Journal of Bioorganic Chemistry, 2017, Vol.43 (3), pp.323-327
来源数据库: Springer Nature Journal
DOI: 10.1134/S1068162017030104
关键词: ParicalcitolVitamin D2Microbial transformationChemical synthesis
原始语种摘要: A novel strategy was developed for the preparation of paricalcitol (1α,25-dihydroxy-19-norvitamin D2) via seven-step chemical transformation and one-step microbial transformation. Using vitamin D2 as a starting material, 1α- and 25-hydroxyl groups of paricalcitol were introduced by Pseudonocardia autotrophica CGMCC5098 at the late stage of the synthesis, allowing us to avoid harsh reaction conditions and tedious steps. The overall yield of paricalcitol was 0.75%.
全文获取路径: Springer Nature  (合作)
影响因子:0.523 (2012)

  • strategy 战略
  • chemical 化学的
  • microbial 微生物的
  • transformation 变换
  • conditions 条件式
  • synthesis 合成
  • novel 长篇小说
  • dihydroxy 二羟
  • combining 组合
  • hydroxyl 羟基