Lower functional connectivity of default mode network in cognitively normal young adults with mutation of APP , presenilins and APOE ε4
作者: Yun Yan SuXiao Dong ZhangU. Joseph SchoepfAkos Varga-SzemesAndrew StubenrauchXue LiangLi Juan ZhengGang ZhengXiang KongQiang XuShou Ju WangRong Feng QiGuang Ming LuLong Jiang Zhang
作者单位: 1Medical School of Nanjing University
2Medical University of South Carolina Ashley River Tower
3Nanjing University of Aeronautics and Astronautics
刊名: Brain Imaging and Behavior, 2017, Vol.11 (3), pp.818-828
来源数据库: Springer Journal
DOI: 10.1007/s11682-016-9556-z
关键词: Default-mode networkApolipoprotein EAmyloid precursor proteinPresenilin-1Presenilin-2Alzheimer’s disease
英文摘要: In this study, we used resting-state functional magnetic resonance imaging to explore the genetic effects of amyloid precursor protein ( APP ) or presenilins mutation and apolipoprotein E ( APOE ) ε4 on the default-mode network (DMN) in cognitively intact young adults (24.1 ± 2.5 years). Both the APP or presenilin-1 / 2 group and the APOE ε4 group had significantly lower DMN functional connectivity (FC) in the some brain regions like precuneus/middle cingulate cortices (PCu/MCC) than controls (AlphaSim corrected, P < 0.05). Only a lower FC tendency was demonstrated (control < APOE ε4 < APP or presenilin-1 / 2 group). Moreover, lower FC in PCu/MCC is correlated with some neuropsychological assessments such as similarity test in APOE ε4 group. These findings indicate that DMN FC alteration...
原始语种摘要: In this study, we used resting-state functional magnetic resonance imaging to explore the genetic effects of amyloid precursor protein ( APP ) or presenilins mutation and apolipoprotein E ( APOE ) ε4 on the default-mode network (DMN) in cognitively intact young adults (24.1 ± 2.5 years). Both the APP or presenilin-1 / 2 group and the APOE ε4 group had significantly lower DMN functional connectivity (FC) in the some brain regions like precuneus/middle cingulate cortices (PCu/MCC) than controls (AlphaSim corrected, P < 0.05). Only a lower FC tendency was demonstrated (control < APOE ε4 < APP or presenilin-1 / 2 group). Moreover, lower FC in PCu/MCC is correlated with some neuropsychological assessments such as similarity test in APOE ε4 group. These findings indicate that DMN FC alteration...
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:2.667 (2012)

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关键词翻译
关键词翻译
  • APP Advanced Placement Program
  • APOE Air Port of Embarkation
  • protein 蛋白质
  • functional 功能的
  • mutation 变种
  • network 网络
  • normal 法线
  • connectivity 连通性
  • intact 完整的
  • preclinical 临证前期的