VEGF isoforms have differential effects on permeability of human pulmonary microvascular endothelial cells
作者: Khadija OurradiThomas BlytheCaroline JarrettShaney L. BarrattGavin I. WelshAnn B. Millar
作者单位: 1University of Bristol
刊名: Respiratory Research, 2017, Vol.18 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12931-017-0602-1
关键词: Vascular permeabilityVascular endothelial growth factor (VEGF)Cell signalling
英文摘要: Alternative splicing of Vascular endothelial growth factor-A mRNA transcripts (commonly referred as VEGF) leads to the generation of functionally differing isoforms, the relative amounts of which have potentially significant physiological outcomes in conditions such as acute respiratory distress syndrome (ARDS). The effect of such isoforms on pulmonary vascular permeability is unknown. We hypothesised that VEGF165a and VEGF165b isoforms would have differing effects on pulmonary vascular permeability caused by differential activation of intercellular signal transduction pathways.
原始语种摘要: Alternative splicing of Vascular endothelial growth factor-A mRNA transcripts (commonly referred as VEGF) leads to the generation of functionally differing isoforms, the relative amounts of which have potentially significant physiological outcomes in conditions such as acute respiratory distress syndrome (ARDS). The effect of such isoforms on pulmonary vascular permeability is unknown. We hypothesised that VEGF165a and VEGF165b isoforms would have differing effects on pulmonary vascular permeability caused by differential activation of intercellular signal transduction pathways.
全文获取路径: Springer  (合作)
分享到:
来源刊物:
影响因子:3.642 (2012)

×
关键词翻译
关键词翻译
  • pulmonary 肺的
  • permeability 磁导率
  • differential 差动的
  • endothelial 内皮的
  • microvascular 微脉管(直径小于0.3 毫米的微血管)的
  • potentially 可能地
  • human 人的
  • splicing 接合
  • signalling 发信号
  • effects 海员自身物品