Role of exosomal proteins in cancer diagnosis
作者: Weihua LiChuanyun LiTong ZhouXiuhong LiuXiaoni LiuXiuhui LiDexi Chen
作者单位: 1Capital Medical University
2Beijing Institute of Hepatology
3Xinjiang Medical University
刊名: Molecular Cancer, 2017, Vol.16 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12943-017-0706-8
关键词: ExosomeCancerDiagnoseBiomarker
英文摘要: Exosomes are emerging as a new type of cancer biomarkers. Exosome is a bilayered nano-sized vesicle secreted by various living cells in all body fluids. Based on the expanding albeit incomplete knowledge of their biogenesis, secretion by cells and cancer cell-specific molecular and genetic contents, exosomes are viewed as promising, clinically-relevant surrogates of cancer progression and response to therapy. Preliminary proteomic, genetic and functional profiling of cancer cell-derived or cancer plasma-derived exosomes confirms their unique characteristics. Alterations in protein or nucleic acid profiles of exosomes in plasma correlate with pathological processes of many diseases including cancer. However, previous studies on exosome application in cancer diagnosis and treatment mainly...
原始语种摘要: Exosomes are emerging as a new type of cancer biomarkers. Exosome is a bilayered nano-sized vesicle secreted by various living cells in all body fluids. Based on the expanding albeit incomplete knowledge of their biogenesis, secretion by cells and cancer cell-specific molecular and genetic contents, exosomes are viewed as promising, clinically-relevant surrogates of cancer progression and response to therapy. Preliminary proteomic, genetic and functional profiling of cancer cell-derived or cancer plasma-derived exosomes confirms their unique characteristics. Alterations in protein or nucleic acid profiles of exosomes in plasma correlate with pathological processes of many diseases including cancer. However, previous studies on exosome application in cancer diagnosis and treatment mainly...
全文获取路径: Springer  (合作)
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影响因子:5.134 (2012)

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关键词翻译
关键词翻译
  • cancer 癌症
  • proteins 蛋白质
  • diagnosis 特镇述
  • prognosis 预报
  • pathological 病理学的
  • exosome 外来体
  • biogenesis 生源说
  • recent 近来的
  • derived 导生的
  • genetic 遗传的