Mutation status coupled with RNA-sequencing data can efficiently identify important non-significantly mutated genes serving as diagnostic biomarkers of endometrial cancer
作者: Keqin LiuLi HeZhichao LiuJunmei XuYuan LiuQifan KuangZhining WenMenglong Li
作者单位: 1Sichuan University
2Biogas Institute of Ministry of Agriculture
3US Food and Drug Administration (FDA)
刊名: BMC Bioinformatics, 2017, Vol.18 (14)
来源数据库: Springer Journal
DOI: 10.1186/s12859-017-1891-6
关键词: Endometrial cancerSomatic mutationRNA sequencingDifferentially expressed genesClinical phenotype characteristics
英文摘要: Endometrial cancers (ECs) are one of the most common types of malignant tumor in females. Substantial efforts had been made to identify significantly mutated genes (SMGs) in ECs and use them as biomarkers for the classification of histological subtypes and the prediction of clinical outcomes. However, the impact of non-significantly mutated genes (non-SMGs), which may also play important roles in the prognosis of EC patients, has not been extensively studied. Therefore, it is essential for the discovery of biomarkers in ECs to further investigate the non-SMGs that were highly associated with clinical outcomes.
原始语种摘要: Endometrial cancers (ECs) are one of the most common types of malignant tumor in females. Substantial efforts had been made to identify significantly mutated genes (SMGs) in ECs and use them as biomarkers for the classification of histological subtypes and the prediction of clinical outcomes. However, the impact of non-significantly mutated genes (non-SMGs), which may also play important roles in the prognosis of EC patients, has not been extensively studied. Therefore, it is essential for the discovery of biomarkers in ECs to further investigate the non-SMGs that were highly associated with clinical outcomes.
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:3.024 (2012)

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关键词翻译
关键词翻译
  • sequencing 排序
  • important 重要的
  • RNA ROYAL NEPAL AIRLINES CORP.
  • identify 视为同一
  • significantly 较大地
  • expressed 榨出的
  • investigate 
  • endometrial 子宫内膜的
  • coupled 耦合
  • serving 电缆外皮