Mesenchymal stem cells for cardiac repair: are the actors ready for the clinical scenario?
作者: Santiago RouraCarolina Gálvez-MontónClémentine MirabelJoaquim VivesAntoni Bayes-Genis
作者单位: 1ICREC Research Program, Germans Trias i Pujol Health Research Institute
2Center of Regenerative Medicine in Barcelona
3CIBERCV, Instituto de Salud Carlos III
4ICREC (Heart Failure and Cardiac Regeneration) Research Programme, Health Sciences Research Institute Germans Trias i Pujol (IGTP)
5Servei de Teràpia Cel∙lular, Banc de Sang i Teixits
6Universitat Autònoma de Barcelona
7Hospital Universitari Germans Trias i Pujol
8Hospital Universitari Germans Trias i Pujol University Hospital
刊名: Stem Cell Research & Therapy, 2017, Vol.8 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s13287-017-0695-y
关键词: Cardiac adipose tissueCardiac repairCell therapyGood manufacturing practiceMesenchymal stem cellsTissue engineeringUmbilical cord blood
原始语种摘要: For years, sufficient progress has been made in treating heart failure following myocardial infarction; however, the social and economic burdens and the costs to world health systems remain high. Moreover, treatment advances have not resolved the underlying problem of functional heart tissue loss. In this field of research, for years we have actively explored innovative biotherapies for cardiac repair. Here, we present a general, critical overview of our experience in using mesenchymal stem cells, derived from cardiac adipose tissue and umbilical cord blood, in a variety of cell therapy and tissue engineering approaches. We also include the latest advances and future challenges, including good manufacturing practice and regulatory issues. Finally, we evaluate whether recent approaches...
全文获取路径: Springer Nature  (合作)
影响因子:3.652 (2012)

  • cells 麻风细胞
  • years 年代
  • repair 修理
  • manufacturing 制造
  • general 普遍的
  • practice 实践
  • adipose 脂肪的
  • following 追踪
  • costs 费用
  • cardiac 贲门