The presence of aberrant p53 pattern is a negative prognostic predictor in squamous cell carcinoma of the nasal vestibule
作者: Domenic VitalGerhard F. HuberDavid HolzmannHolger MochKristian Ikenberg
作者单位: 1Zurich University Hospital and University of Zurich
刊名: European Archives of Oto-Rhino-Laryngology, 2017, Vol.274 (9), pp.3503-3512
来源数据库: Springer Journal
DOI: 10.1007/s00405-017-4659-8
关键词: Squamous cell carcinomaNasal vestibuleP53Aberrant patternKi-67Predictor
英文摘要: The aim of this study was to analyze the role of Ki-67, p53, and the “aberrant p53 pattern” in squamous cell carcinomas of the nasal vestibule. Patients between 1995 and 2014 were included. Baseline characteristics and outcome were analyzed with respect to immunohistochemical staining of Ki-67 and p53. “Aberrant p53 pattern” was represented by a moderate or strong staining of at least 60% of the tumor cells or a complete absence of immunoreactivity. Forty-six patients were included of whom 31 (67.4%) were available for Ki-67 and 32 (69.9%) for p53 immunohistochemistry. The “aberrant pattern” of p53 was present in 50% of the patients. While immunoreactivity for both Ki-67 and p53 was not related to each other or outcome, the “aberrant p53 pattern” was associated with a worse disease-free...
原始语种摘要: The aim of this study was to analyze the role of Ki-67, p53, and the “aberrant p53 pattern” in squamous cell carcinomas of the nasal vestibule. Patients between 1995 and 2014 were included. Baseline characteristics and outcome were analyzed with respect to immunohistochemical staining of Ki-67 and p53. “Aberrant p53 pattern” was represented by a moderate or strong staining of at least 60% of the tumor cells or a complete absence of immunoreactivity. Forty-six patients were included of whom 31 (67.4%) were available for Ki-67 and 32 (69.9%) for p53 immunohistochemistry. The “aberrant pattern” of p53 was present in 50% of the patients. While immunoreactivity for both Ki-67 and p53 was not related to each other or outcome, the “aberrant p53 pattern” was associated with a worse disease-free...
全文获取路径: Springer  (合作)
分享到:
来源刊物:
影响因子:1.458 (2012)

×
关键词翻译
关键词翻译
  • vestibule 门厅
  • squamous 具鳞的
  • carcinoma 癌症
  • aberrant 异常的
  • nasal 鼻的
  • prognostic 预测的
  • pattern 模型
  • predictor 预示
  • survival 生存
  • moderate 适当的