N-butanol extracts of Morinda citrifolia suppress advanced glycation end products (AGE)-induced inflammatory reactions in endothelial cells through its anti-oxidative properties
作者: Yuji IshibashiTakanori MatsuiFumiyuki IsamiYumi AbeTatsuya SakaguchiYuichiro HigashimotoSho-ichi Yamagishi
作者单位: 1Kurume University School of Medicine
2Morinda Worldwide Inc.
刊名: BMC Complementary and Alternative Medicine, 2017, Vol.17 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12906-017-1641-3
关键词: AGEsRAGEOxidative stressAtherosclerosis
英文摘要: Advanced glycation end products (AGEs), senescent macroprotein derivatives formed during a normal aging process and acceleratedly under diabetic conditions, play a role in atherosclerotic cardiovascular disease. AGEs cause endothelial cell (EC) damage, an initial trigger for atherosclerosis through the interaction with a receptor for AGEs (RAGE). We have previously shown that n-butanol extracts of Morinda citrifolia (noni), a plant belonging to the family Rubiaceae, block the binding of AGEs to RAGE in vitro. In this study, we examined the effects of n-butanol extracts of noni on reactive oxygen species (ROS) generation and inflammatory reactions on AGE-exposed human umbilical vein ECs (HUVECs).
原始语种摘要: Advanced glycation end products (AGEs), senescent macroprotein derivatives formed during a normal aging process and acceleratedly under diabetic conditions, play a role in atherosclerotic cardiovascular disease. AGEs cause endothelial cell (EC) damage, an initial trigger for atherosclerosis through the interaction with a receptor for AGEs (RAGE). We have previously shown that n-butanol extracts of Morinda citrifolia (noni), a plant belonging to the family Rubiaceae, block the binding of AGEs to RAGE in vitro. In this study, we examined the effects of n-butanol extracts of noni on reactive oxygen species (ROS) generation and inflammatory reactions on AGE-exposed human umbilical vein ECs (HUVECs).
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:2.082 (2012)

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关键词翻译
关键词翻译
  • extracts 摘记
  • AGE Aircraft Ground Equipment
  • inflammatory 激怒的
  • endothelial 内皮的
  • induced 感应的
  • butanol 丁醇
  • products 制品
  • oxidative 氧化的
  • umbilical 供应脐带
  • through 经过