In utero exposure to germinated brown rice and its oryzanol-rich extract attenuated high fat diet-induced insulin resistance in F1 generation of rats
作者: Hadiza Altine AdamuMustapha Umar ImamDer-Jiun OoiNorhaizan Mohd EsaRozita RosliMaznah Ismail
作者单位: 1Universiti Putra Malaysia
刊名: BMC Complementary and Alternative Medicine, 2017, Vol.17 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12906-017-1571-0
关键词: DNA methylationEpigeneticsGerminated brown riceGamma oryzanolHistone acetylationInsulin resistanceNutrigenomics
英文摘要: The development of insulin resistance is multifactorial, with maternal pre- and postnatal nutrition having significant influences. In this regard, high fat diet (HFD) feeding in pregnancy has been shown to increase risks of metabolic diseases. Thus, we investigated the effects of supplementation of HFD with germinated brown rice (GBR) and GBR-derived gamma oryzanol-rich extract (OE) on insulin resistance and its epigenetic implications in pregnant rats and their offsprings.
原始语种摘要: The development of insulin resistance is multifactorial, with maternal pre- and postnatal nutrition having significant influences. In this regard, high fat diet (HFD) feeding in pregnancy has been shown to increase risks of metabolic diseases. Thus, we investigated the effects of supplementation of HFD with germinated brown rice (GBR) and GBR-derived gamma oryzanol-rich extract (OE) on insulin resistance and its epigenetic implications in pregnant rats and their offsprings.
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:2.082 (2012)

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关键词翻译
关键词翻译
  • oryzanol 谷维素
  • resistance 抵抗
  • insulin 胰岛素
  • brown 褐色
  • generation 世代
  • multifactorial 多因子的
  • epigenetic 后成的
  • acetylation 乙酰化
  • pregnant 怀孕的
  • postnatal 出生后的