Brain white matter changes in asymptomatic carriers of Leber’s hereditary optic neuropathy
作者: Miaomiao LongLing WangQin TianHao DingWen QinDapeng ShiChunshui Yu
作者单位: 1Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital
2Department of Radiology, Tianjin First Central Hospital
3Department of Radiology, Zhengzhou University People’s Hospital, Henan Provincial People’s Hospital
4Henan Key Laboratory for Medical Imaging of Neurological Disease
刊名: Journal of Neurology, 2019, Vol.266 (6), pp.1474-1480
来源数据库: Springer Nature Journal
DOI: 10.1007/s00415-019-09284-2
关键词: Leber’s hereditary optic neuropathyDiffusion tensor imagingTract-based spatial statisticsRetinal nerve fiber layerWhite matterCarriers
原始语种摘要: Abstract(#br) Objective(#br)Subclinical abnormalities, including microangiopathy, swelling of nerve fibers, visual field abnormalities and visual functional impairments had been reported in Leber’s hereditary optic neuropathy (LHON) carriers. The purpose of this study was to investigate microstructural changes of brain white matter in asymptomatic LHON carriers using DTI and tract-based spatial statistics (TBSS).(#br) Methods(#br)DTI and neuro-ophthalmologic measurements were acquired in 14 LHON carriers and 15 gender- and age-matched healthy controls, and diffusion metrics, including fractional anisotropy (FA), axial (AD), radial diffusion (RD) and mean diffusion (MD) were calculated. Intergroup differences in diffusion metrics were compared regressing out potential nuisance covariates...
全文获取路径: Springer Nature  (合作)
影响因子:3.578 (2012)