Low expression of CD39 and CD73 genes in centenarians compared with octogenarians
作者: Almudena CrookeJuan Martínez-HenándezJoaquín Martínez-LópezAlfonso Cruz-JentoftFernando Huete-ToralJesús Pintor
作者单位: 1Universidad Complutense de Madrid
2Fundación para la Formación
3Hospital Universitario 12 de Octubre
4Hospital Universitario Ramón y Cajal
刊名: Immunity & Ageing, 2017, Vol.14 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12979-017-0094-3
关键词: AgeingCentenarianAdenosine receptorEcto-nucleotidase
英文摘要: Ageing involves a progressive decline of the body’s regulatory systems including immune system. Adenosine regulates immune function by interaction with its receptors, mainly adenosine A2A receptor, present on the surface of immune cells. Furthermore, cellular response to this nucleoside is highly dependent on its extracellular concentration that is regulated by ecto-enzymes such as CD39 and CD73. Therefore, the aim of this study was to investigate the effect of age on adenosine A2A receptor, CD39 and CD73 gene expression. Changes in mRNA were measured by quantitative PCR from peripheral blood of young, middle-aged and older adults as well as centenarians. Centenarians showed a prominent decrease of CD39 and CD73 mRNA in comparison with older adults. Regarding to adenosine A2A receptor, we...
原始语种摘要: Ageing involves a progressive decline of the body’s regulatory systems including immune system. Adenosine regulates immune function by interaction with its receptors, mainly adenosine A2A receptor, present on the surface of immune cells. Furthermore, cellular response to this nucleoside is highly dependent on its extracellular concentration that is regulated by ecto-enzymes such as CD39 and CD73. Therefore, the aim of this study was to investigate the effect of age on adenosine A2A receptor, CD39 and CD73 gene expression. Changes in mRNA were measured by quantitative PCR from peripheral blood of young, middle-aged and older adults as well as centenarians. Centenarians showed a prominent decrease of CD39 and CD73 mRNA in comparison with older adults. Regarding to adenosine A2A receptor, we...
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关键词翻译
关键词翻译
  • receptor 接受体
  • expression 表示
  • immune 免疫的
  • nucleotidase 核苷酸酶
  • adenosine 腺苷
  • regulatory 控制的
  • enzymes 酶类
  • compared 肿瘤和正常组织细胞周期的比较
  • mRNA m核糖核酸
  • correlate 联系数