SLC30A8 polymorphism and BMI complement HLA-A*24 as risk factors for poor graft function in islet allograft recipients
作者: Else M. BalkeSimke DemeesterDaHae LeePieter GillardRobert HilbrandsUrsule VeldeBart J. AuweraZhidong LingBart O. RoepDaniël G. PipeleersBart KeymeulenFrans K. Gorus
作者单位: 1Diabetes Research Center, Vrije Universiteit Brussel
2Department of Endocrinology, University Hospitals Leuven
3Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center
4Department of Diabetes Immunology, Diabetes and Metabolism Research Institute, Beckman Research Institute at the City of Hope
刊名: Diabetologia, 2018, Vol.61 (7), pp.1623-1632
来源数据库: Springer Nature Journal
DOI: 10.1007/s00125-018-4609-z
关键词: Body mass indexGenetics of type 1 diabetesHLA class IHuman islet transplantationZinc transporter 8
原始语种摘要: Abstract(#br) Aims/hypothesis(#br) HLA-A*24 carriership hampers achievement of insulin independence in islet allograft recipients. However, less than half of those who fail to achieve insulin independence carry the allele. We investigated whether genetic polymorphism at the recipients’ zinc transporter 8-encoding SLC30A8 gene (rs13266634) could complement their HLA-A*24 status in predicting functional graft outcome.(#br) Methods(#br)We retrospectively analysed data of a hospital-based patient cohort followed for 18 months post transplantation. Forty C-peptide-negative type 1 diabetic individuals who received >2 million beta cells (>4000 islet equivalents) per kg body weight in one or two intraportal implantations under similar immunosuppression were genotyped for SLC30A8 . Outcome...
全文获取路径: Springer Nature  (合作)
影响因子:6.487 (2012)