Coinfection with koala retrovirus subtypes A and B and its impact on captive koalas in Japanese zoos
作者: Md Abul HashemMohammad Enamul Hoque KayeshOsamu YamatoFumie MaetaniTaiki EieiKyoya MochizukiHiroko SakuraiAyaka ItoHiroki KannnoTatsuya KasaharaYusuke AmanoKyoko Tsukiyama-Kohara
作者单位: 1Laboratory of Animal Hygiene, Joint Faculty of Veterinary Medicine, Kagoshima University
2Transboundary Animal Diseases Centre, Department of Animal Hygiene, Joint Faculty of Veterinary Medicine, Kagoshima University
3Department of Health, Chittagong City Corporation
4Department of Pathological and Preventive Veterinary Science, The United Graduate School of Veterinary Science, Yamaguchi University
5Department of Microbiology and Public Health, Patuakhali Science and Technology University
6Department of Clinical Pathology, Joint Faculty of Veterinary Medicine, Kagoshima University
7Hirakawa Zoological Park
8Kobe Oji Zoo
9Saitama Children’s Zoo
刊名: Archives of Virology, 2019, Vol.164 (11), pp.2735-2745
来源数据库: Springer Nature Journal
DOI: 10.1007/s00705-019-04392-w
英文摘要: Abstract(#br)Koala retrovirus (KoRV) is unique among endogenous retroviruses because its endogenization is still active. Two major KoRV subtypes, KoRV-A and B, have been described, and KoRV-B is associated with disease and poses a health threat to koalas. Here, we investigated the co-prevalence of KoRV-A and KoRV-B, detected by type-specific PCR and sequencing, and their impact on the health of koalas in three Japanese zoos. We also investigated KoRV proviral loads and found varying amounts of genomic DNA (gDNA) in peripheral blood mononuclear cells (PBMCs). We found that 100% of the koalas examined were infected with KoRV-A and 60% (12/20) were coinfected with KoRV-B. The KoRV-A sequence was highly conserved, whereas the KoRV-B sequence varied among individuals. Interestingly, we...
全文获取路径: Springer Nature  (合作)
影响因子:2.03 (2012)