SNP by SNP by environment interaction network of alcoholism
作者: Amin ZollanvariGil Alterovitz
作者单位: 1Nazarbayev University
2Harvard Medical School
3Massachusetts Institute of Technology
刊名: BMC Systems Biology, 2017, Vol.11 (3)
来源数据库: Springer Journal
DOI: 10.1186/s12918-017-0403-7
关键词: GWASAlcoholismSNPEnvironmentInteractionNetwork
英文摘要: Alcoholism has a strong genetic component. Twin studies have demonstrated the heritability of a large proportion of phenotypic variance of alcoholism ranging from 50–80%. The search for genetic variants associated with this complex behavior has epitomized sequence-based studies for nearly a decade. The limited success of genome-wide association studies (GWAS), possibly precipitated by the polygenic nature of complex traits and behaviors, however, has demonstrated the need for novel, multivariate models capable of quantitatively capturing interactions between a host of genetic variants and their association with non-genetic factors. In this regard, capturing the network of SNP by SNP or SNP by environment interactions has recently gained much interest.
原始语种摘要: Alcoholism has a strong genetic component. Twin studies have demonstrated the heritability of a large proportion of phenotypic variance of alcoholism ranging from 50–80%. The search for genetic variants associated with this complex behavior has epitomized sequence-based studies for nearly a decade. The limited success of genome-wide association studies (GWAS), possibly precipitated by the polygenic nature of complex traits and behaviors, however, has demonstrated the need for novel, multivariate models capable of quantitatively capturing interactions between a host of genetic variants and their association with non-genetic factors. In this regard, capturing the network of SNP by SNP or SNP by environment interactions has recently gained much interest.
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:2.982 (2012)

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关键词翻译
关键词翻译
  • genetic 遗传的
  • demonstrated 探明的储量
  • alcoholism 酒中毒
  • network 网络
  • possibly 无论如何
  • association 联合
  • complex 超群
  • heritability 遗传力
  • quantitatively 定量的
  • however 然而