Bone Alkaline Phosphatase and Tartrate-Resistant Acid Phosphatase: Potential Co-regulators of Bone Mineralization
作者: Cecilia Halling LinderBarbro Ek-RylanderMichael KrumpelMaria NorgårdSonoko NarisawaJosé Luis MillánGöran AnderssonPer Magnusson
作者单位: 1Linköping University
2Karolinska Institutet
3Sanford Burnham Prebys Medical Discovery Institute
刊名: Calcified Tissue International, 2017, Vol.101 (1), pp.92-101
来源数据库: Springer Nature Journal
DOI: 10.1007/s00223-017-0259-2
关键词: BoneDephosphorylationHydroxyapatiteInorganic pyrophosphateMineralizationOsteopontin
英文摘要: Phosphorylated osteopontin (OPN) inhibits hydroxyapatite crystal formation and growth, and bone alkaline phosphatase (BALP) promotes extracellular mineralization via the release of inorganic phosphate from the mineralization inhibitor inorganic pyrophosphate (PPi). Tartrate-resistant acid phosphatase (TRAP), produced by osteoclasts, osteoblasts, and osteocytes, exhibits potent phosphatase activity towards OPN; however, its potential capacity as a regulator of mineralization has not previously been addressed. We compared the efficiency of BALP and TRAP towards the endogenous substrates for BALP, i.e., PPi and pyridoxal 5′-phosphate (PLP), and their impact on mineralization in vitro via dephosphorylation of bovine milk OPN. TRAP showed higher phosphatase activity towards phosphorylated OPN...
原始语种摘要: Phosphorylated osteopontin (OPN) inhibits hydroxyapatite crystal formation and growth, and bone alkaline phosphatase (BALP) promotes extracellular mineralization via the release of inorganic phosphate from the mineralization inhibitor inorganic pyrophosphate (PPi). Tartrate-resistant acid phosphatase (TRAP), produced by osteoclasts, osteoblasts, and osteocytes, exhibits potent phosphatase activity towards OPN; however, its potential capacity as a regulator of mineralization has not previously been addressed. We compared the efficiency of BALP and TRAP towards the endogenous substrates for BALP, i.e., PPi and pyridoxal 5′-phosphate (PLP), and their impact on mineralization in vitro via dephosphorylation of bovine milk OPN. TRAP showed higher phosphatase activity towards phosphorylated OPN...
全文获取路径: Springer Nature  (合作)
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影响因子:2.495 (2012)

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关键词翻译
关键词翻译
  • pyrophosphate 焦磷酸盐
  • phosphatase 磷酸酶
  • OPN 打开
  • mineralization 成矿酌
  • mineralized 矿化
  • regulator 第器
  • towards 朝向
  • alkaline 碱的
  • resistant 耐久的
  • potential