An Active Drimane-Type Lactone from Polygonum jucundum Attenuates Lipopolysaccharide-Induced Acute Lung Injury in Mice Through TLR4-MAPKs Signaling Pathway
作者: Yang HuLijun TaoHui TanMian ZhangKuniyoshi ShimizuFei ZhangChaofeng Zhang
作者单位: 1China Pharmaceutical University
2Kyushu University
3Jiangsu Simcere Pharmaceutical Group Ltd.
刊名: Inflammation, 2017, Vol.40 (4), pp.1204-1213
来源数据库: Springer Journal
DOI: 10.1007/s10753-017-0563-z
关键词: 2α-Hydroxyl-3β-angeloylcinnamolideToll-like receptor 4Mitogen-activated protein kinasesAcute lung injuryAnti-inflammation
英文摘要: The herbs of Polygonum jucundum Lindex. (Polygonaceae) is a traditional Chinese medicine for inflammatory diseases. 2α-Hydroxyl-3β-angeloylcinnamolide (HAC), a drimane-type sesquiterpenoid, was the major active compound of the ethanol extract of P. jucundum which inhibited the production of inflammatory mediators. However, the biological mechanism of HAC for anti-inflammatory activity has not been reported. In the current study, we investigated whether HAC could suppress the production of inflammatory mediators in lipopolysaccharide (LPS)-induced acute lung injury in mice (ALI) through downregulation of Toll-like receptor 4 (TLR4) and activations of mitogen-activated protein kinases (MAPKs) and inducible protein nitric oxide synthase (iNOS). Moreover, our data indicated that HAC inhibits...
原始语种摘要: The herbs of Polygonum jucundum Lindex. (Polygonaceae) is a traditional Chinese medicine for inflammatory diseases. 2α-Hydroxyl-3β-angeloylcinnamolide (HAC), a drimane-type sesquiterpenoid, was the major active compound of the ethanol extract of P. jucundum which inhibited the production of inflammatory mediators. However, the biological mechanism of HAC for anti-inflammatory activity has not been reported. In the current study, we investigated whether HAC could suppress the production of inflammatory mediators in lipopolysaccharide (LPS)-induced acute lung injury in mice (ALI) through downregulation of Toll-like receptor 4 (TLR4) and activations of mitogen-activated protein kinases (MAPKs) and inducible protein nitric oxide synthase (iNOS). Moreover, our data indicated that HAC inhibits...
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:2.457 (2012)

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关键词翻译
关键词翻译
  • Polygonum 蓼属
  • inflammatory 激怒的
  • suppressing 制止的
  • protein 蛋白质
  • nitric 氮的
  • macrophages 巨噬细胞
  • treated 加工的
  • LPS Laboratory Peripheral System
  • inflammation 炎症
  • compound 复合物