Using a novel PV-Cre rat model to characterize pallidonigral cells and their terminations
作者: Yoon-Mi OhFuyuki KarubeSusumu TakahashiKenta KobayashiMasahiko TakadaMotokazu UchigashimaMasahiko WatanabeKayo NishizawaKazuto KobayashiFumino Fujiyama
作者单位: 1Doshisha University
2National Institute for Physiological Sciences
3Kyoto University
4Hokkaido University Graduate School of Medicine
5Fukushima Medical University
刊名: Brain Structure and Function, 2017, Vol.222 (5), pp.2359-2378
来源数据库: Springer Journal
DOI: 10.1007/s00429-016-1346-2
关键词: Globus pallidusBasal gangliaDopamine neuronSubstantia nigra
英文摘要: In the present study, we generated a novel parvalbumin (PV)-Cre rat model and conducted detailed morphological and electrophysiological investigations of axons from PV neurons in globus pallidus (GP). The GP is considered as a relay nucleus in the indirect pathway of the basal ganglia (BG). Previous studies have used molecular profiling and projection patterns to demonstrate cellular heterogeneity in the GP; for example, PV-expressing neurons are known to comprise approximately 50% of GP neurons and represent majority of prototypic neurons that project to the subthalamic nucleus and/or output nuclei of BG, entopeduncular nucleus and substantia nigra (SN). The present study aimed to identify the characteristic projection patterns of PV neurons in the GP (PV-GP neurons) and determine...
原始语种摘要: In the present study, we generated a novel parvalbumin (PV)-Cre rat model and conducted detailed morphological and electrophysiological investigations of axons from PV neurons in globus pallidus (GP). The GP is considered as a relay nucleus in the indirect pathway of the basal ganglia (BG). Previous studies have used molecular profiling and projection patterns to demonstrate cellular heterogeneity in the GP; for example, PV-expressing neurons are known to comprise approximately 50% of GP neurons and represent majority of prototypic neurons that project to the subthalamic nucleus and/or output nuclei of BG, entopeduncular nucleus and substantia nigra (SN). The present study aimed to identify the characteristic projection patterns of PV neurons in the GP (PV-GP neurons) and determine...
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来源刊物:
影响因子:7.837 (2012)

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关键词翻译
关键词翻译
  • dopamine 多巴胺
  • nigra 黑质
  • subthalamic 丘脑下的
  • substantia 
  • hydroxylase 羟基化酶
  • characterize 成为...的特性
  • novel 长篇小说
  • ganglia 神经节
  • demonstrated 探明的储量
  • present 出席的