Production of 3-hydroxypropionic acid in engineered Methylobacterium extorquens AM1 and its reassimilation through a reductive route
作者: Yi-Ming YangWen-Jing ChenJing YangYuan-Ming ZhouBo HuMin ZhangLi-Ping ZhuGuang-Yuan WangSong Yang
作者单位: 1Qingdao Agricultural University, Shandong Province Key Laboratory of Applied Mycology, and Qingdao International Center on Microbes Utilizing Biogas
2Qingdao Agricultural University
3University of Washington
4Intrexon Corporation
5Qingdao Agricultural University, Shandong P
刊名: Microbial Cell Factories, 2017, Vol.16 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12934-017-0798-2
关键词: Methylobacterium extorquensMethanol3-Hydroxypropionic acidReassimilationReductive route13C-labeling
原始语种摘要: 3-Hydroxypropionic acid (3-HP) is an important platform chemical, serving as a precursor for a wide range of industrial applications such as the production of acrylic acid and 1,3-propanediol. Although Escherichia coli or Saccharomyces cerevisiae are the primary industrial microbes for the production of 3-HP, alternative engineered hosts have the potential to generate 3-HP from other carbon feedstocks. Methylobacterium extorquens AM1, a facultative methylotrophic α-proteobacterium, is a model system for assessing the possibility of generating 3-HP from one-carbon feedstock methanol.
全文获取路径: Springer Nature  (合作)
影响因子:3.306 (2012)

  • reductive 减少的
  • through 经过
  • facultative 随意的
  • route 航线
  • chemical 化学的
  • range 射程
  • microbes 微生物
  • industrial 工业的
  • engineered 设计的
  • carbon