Lung adenocarcinoma expressing receptor for advanced glycation end-products with primary systemic AL amyloidosis: a case report and literature review
作者: Shouichi OkamotoShinsaku TogoIchiro NagataKazue ShimizuYoshika KoinumaYukiko NambaJun ItoToshimasa UekusaKazuhisa Takahashi
作者单位: 1Juntendo University School of Medicine & Graduate School of Medicine
2Juntendo University Graduate School of Medicine
3Junior Resident of Juntendo University Hospital
4Department of Pathology, Labor Health and Welfare Organization Kanto Rosai Hospital
刊名: BMC Cancer, 2017, Vol.17 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12885-016-3009-3
关键词: AmyloidosisCase reportLung adenocarcinomaRAGE
英文摘要: Receptor for advanced glycation end-products (RAGE), a receptor for amyloids, is constitutively expressed in lungs and generally observed to be downregulated in lung cancer tissues. However, increasing levels of RAGE or serum amyloids is associated with poor outcome in lung cancer patients. We report a rare case of primary systemic amyloid light-chain (AL) amyloidosis in biopsy-proven multiple organs with early-stage non-small cell lung cancer (NSCLC) that displayed strong staining for RAGE in the tumour tissue. Interestingly, compared with randomly selected lung cancer biopsy samples, including all representative histological subtypes of NSCLC and small-cell lung cancer, only the NSCLC in the present case showed strong expression for RAGE that can bind amyloids.
原始语种摘要: Receptor for advanced glycation end-products (RAGE), a receptor for amyloids, is constitutively expressed in lungs and generally observed to be downregulated in lung cancer tissues. However, increasing levels of RAGE or serum amyloids is associated with poor outcome in lung cancer patients. We report a rare case of primary systemic amyloid light-chain (AL) amyloidosis in biopsy-proven multiple organs with early-stage non-small cell lung cancer (NSCLC) that displayed strong staining for RAGE in the tumour tissue. Interestingly, compared with randomly selected lung cancer biopsy samples, including all representative histological subtypes of NSCLC and small-cell lung cancer, only the NSCLC in the present case showed strong expression for RAGE that can bind amyloids.
全文获取路径: Springer  (合作)
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影响因子:3.333 (2012)

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关键词翻译
关键词翻译
  • adenocarcinoma 腺癌
  • amyloidosis 淀粉样变性
  • literature 文献
  • systemic 系统的
  • receptor 接受体
  • expressing 压榨
  • primary 一次的
  • report 通报
  • cancer 癌症
  • products 制品