Accessing gap-junction channel structure-function relationships through molecular modeling and simulations
作者: F. VillaneloY. EscalonaC. Pareja-BarruetoJ. A. GarateI. M. SkerrettT. Perez-Acle
作者单位: 1Computational Biology Lab. Fundación Ciencia & Vida
2Universidad de Valparaíso
3State University of New York (SUNY) Buffalo State
刊名: BMC Cell Biology, 2017, Vol.18 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12860-016-0121-9
关键词: ConnexinsHemichannelsGap-junction channelsStructure and functionMolecular simulationHomology modeling
英文摘要: Gap junction channels (GJCs) are massive protein channels connecting the cytoplasm of adjacent cells. These channels allow intercellular transfer of molecules up to ~1 kDa, including water, ions and other metabolites. Unveiling structure-function relationships coded into the molecular architecture of these channels is necessary to gain insight on their vast biological function including electrical synapse, inflammation, development and tissular homeostasis. From early works, computational methods have been critical to analyze and interpret experimental observations. Upon the availability of crystallographic structures, molecular modeling and simulations have become a valuable tool to assess structure-function relationships in GJCs. Modeling different connexin isoforms, simulating the...
原始语种摘要: Gap junction channels (GJCs) are massive protein channels connecting the cytoplasm of adjacent cells. These channels allow intercellular transfer of molecules up to ~1 kDa, including water, ions and other metabolites. Unveiling structure-function relationships coded into the molecular architecture of these channels is necessary to gain insight on their vast biological function including electrical synapse, inflammation, development and tissular homeostasis. From early works, computational methods have been critical to analyze and interpret experimental observations. Upon the availability of crystallographic structures, molecular modeling and simulations have become a valuable tool to assess structure-function relationships in GJCs. Modeling different connexin isoforms, simulating the...
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:2.808 (2012)

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关键词翻译
关键词翻译
  • modeling 制祝型
  • junction 连接
  • function 函数
  • molecular 分子的
  • structure 构造
  • channel 槽水道
  • electrical 电的
  • architecture 构造
  • computational 计算的
  • tissular 组织的