Serum proteomic profiling for autism using magnetic bead-assisted matrix-assisted laser desorption ionization time-of-flight mass spectrometry: a pilot study
作者: Yan-Ni ChenHui-Ying DuZhuo-Yue ShiLi HeYu-Ying HeDuan Wang
作者单位: 1Department of Health Care, Xi’an Children’s Hospital, Xi’an Jiaotong University
2Department of Biology, College of Liberal Arts and Science, The University of Iowa
3Department of Pediatrics, Shaanxi University of Chinese Medicine
4Xi’an Maternal and Child Health Hospital
刊名: World Journal of Pediatrics, 2018, Vol.14 (3), pp.233-237
来源数据库: Springer Journal
DOI: 10.1007/s12519-017-0102-x
关键词: AutismMatrix-assisted laser desorption ionization time-of-flight mass spectrometryProteomic profilingWeak cation-exchange chromatography magnetic beads
英文摘要: Abstract(#br) Background(#br)The pathogenesis of autism spectrum disorders remains elusive and currently there are no diagnostic or predictive biomarkers in autism available. Proteomic profiling has been used in a wide range of neurodevelopmental disorder studies, which could produce deeper perceptions of the molecular bases behind certain disease and potentially becomes useful in discovering biomarkers in autism spectrum disorders.(#br) Methods(#br)Serum samples were collected from autistic children about 3 years old in age ( n = 32) and healthy controls ( n = 20) in similar age and gender. The samples were identified specific proteins that are differentially expressed by magnetic bead-based pre-fractionation and matrix-assisted laser desorption ionization time-of-flight mass...
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影响因子:1.084 (2012)

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