Advanced glycation end products attenuate the function of tumor necrosis factor-like weak inducer of apoptosis to regulate the inflammatory response
作者: Masahiro WatanabeTakao ToyomuraHidenori WakeKeyue LiuKiyoshi TeshigawaraHideo TakahashiMasahiro NishiboriShuji Mori
作者单位: 1Shujitsu University
2Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
3Kindai University
刊名: Molecular and Cellular Biochemistry, 2017, Vol.434 (1-2), pp.153-162
来源数据库: Springer Journal
DOI: 10.1007/s11010-017-3045-6
关键词: Advanced glycation end productsInflammatory responseCytokineTumor necrosis factor
英文摘要: Advanced glycation end products (AGEs) are formed from the non-enzymatic glycation reaction of reducing sugars or their metabolites with the free amino groups of several biomolecules and are known to play pathophysiological roles in various inflammatory diseases. In an earlier study, it was suggested that tumor necrosis factor-like weak inducer of apoptosis (TWEAK) has a unique role to regulate the tumor necrosis factor α (TNFα)-induced inflammatory response. In this study, we investigated the effect of the AGEs–TWEAK interaction on proinflammatory signaling responses in endothelial cells and the influence of AGEs on the cellular function of TWEAK in the inflammatory process. The effect of AGEs on the TWEAK/TNFα-induced gene expression of interleukin-8 (IL-8) was determined by real-time...
原始语种摘要: Advanced glycation end products (AGEs) are formed from the non-enzymatic glycation reaction of reducing sugars or their metabolites with the free amino groups of several biomolecules and are known to play pathophysiological roles in various inflammatory diseases. In an earlier study, it was suggested that tumor necrosis factor-like weak inducer of apoptosis (TWEAK) has a unique role to regulate the tumor necrosis factor α (TNFα)-induced inflammatory response. In this study, we investigated the effect of the AGEs–TWEAK interaction on proinflammatory signaling responses in endothelial cells and the influence of AGEs on the cellular function of TWEAK in the inflammatory process. The effect of AGEs on the TWEAK/TNFα-induced gene expression of interleukin-8 (IL-8) was determined by real-time...
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来源刊物:
影响因子:2.329 (2012)

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关键词翻译
关键词翻译
  • inflammatory 激怒的
  • attenuate 衰减
  • necrosis 坏死
  • pretreatment 预处理
  • induced 感应的
  • factor 因素
  • products 制品
  • canonical 标准的
  • activation 活化
  • apoptosis 细胞死