Tissue-engineered smooth muscle cell and endothelial progenitor cell bi-level cell sheets prevent progression of cardiac dysfunction, microvascular dysfunction, and interstitial fibrosis in a rodent model of type 1 diabetes-induced cardiomyopathy
作者: Masashi KawamuraMichael J. PaulsenAndrew B. GoldstoneYasuhiro ShudoHanjay WangAmanda N. SteeleLyndsay M. StapletonBryan B. EdwardsAnahita EskandariVi N. TruongKevin J. JaatinenArnar B. IngasonShigeru MiyagawaYoshiki SawaY. Joseph Woo
作者单位: 1Stanford University School of Medicine
2Osaka University Graduate School of Medicine
刊名: Cardiovascular Diabetology, 2017, Vol.16 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12933-017-0625-4
关键词: Diabetic cardiomyopathyTissue engineeringCell therapy
英文摘要: Diabetes mellitus is a risk factor for coronary artery disease and diabetic cardiomyopathy, and adversely impacts outcomes following coronary artery bypass grafting. Current treatments focus on macro-revascularization and neglect the microvascular disease typical of diabetes mellitus-induced cardiomyopathy (DMCM). We hypothesized that engineered smooth muscle cell (SMC)-endothelial progenitor cell (EPC) bi-level cell sheets could improve ventricular dysfunction in DMCM.
原始语种摘要: Diabetes mellitus is a risk factor for coronary artery disease and diabetic cardiomyopathy, and adversely impacts outcomes following coronary artery bypass grafting. Current treatments focus on macro-revascularization and neglect the microvascular disease typical of diabetes mellitus-induced cardiomyopathy (DMCM). We hypothesized that engineered smooth muscle cell (SMC)-endothelial progenitor cell (EPC) bi-level cell sheets could improve ventricular dysfunction in DMCM.
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:4.209 (2012)

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关键词翻译
关键词翻译
  • cardiomyopathy 心肌病
  • diabetes 糖尿病
  • prevent 避免
  • microvascular 微脉管(直径小于0.3 毫米的微血管)的
  • interstitial 间隙原子
  • muscle 肌肉
  • fibrosis 纤维化
  • induced 感应的
  • smooth 平滑的
  • progenitor 祖先