Differential gene expression in Anopheles stephensi following infection with drug-resistant Plasmodium yoelii
作者: Jingru ZhangJiacheng HuangFeng ZhuJian Zhang
作者单位: 1the Third Military Medical University
2Students brigade 5, The Third Military Medical University
刊名: Parasites & Vectors, 2017, Vol.10 (1)
来源数据库: Springer Journal
DOI: 10.1186/s13071-017-2326-y
关键词: Differential gene expressionAnophelesDrug-resistant Plasmodium
英文摘要: The transmission of drug-resistant parasites by the mosquito may be influenced by the altered biological fitness of drug-resistant parasites and different immune reactions or metabolic change in the mosquito. At this point, little is known about the variations in mosquito immunity and metabolism when mosquitoes are infected with drug-resistant parasites. To understand the differential gene expression in Anopheles following infection with drug-resistant Plasmodium , we conducted a genome-wide transcriptomic profiling analysis of Anopheles stephensi following feeding on mice with drug-resistant or drug-sensitive P. yoelii , observed changes in gene expression profiles and identified transcripts affected by the drug-resistant parasite.
原始语种摘要: The transmission of drug-resistant parasites by the mosquito may be influenced by the altered biological fitness of drug-resistant parasites and different immune reactions or metabolic change in the mosquito. At this point, little is known about the variations in mosquito immunity and metabolism when mosquitoes are infected with drug-resistant parasites. To understand the differential gene expression in Anopheles following infection with drug-resistant Plasmodium , we conducted a genome-wide transcriptomic profiling analysis of Anopheles stephensi following feeding on mice with drug-resistant or drug-sensitive P. yoelii , observed changes in gene expression profiles and identified transcripts affected by the drug-resistant parasite.
全文获取路径: Springer  (合作)
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影响因子:3.246 (2012)

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关键词翻译
关键词翻译
  • expression 表示
  • resistant 耐久的
  • parasites 天电干扰
  • observed 观察到的
  • differential 差动的
  • mosquito 蚊子
  • known 己知
  • sensitive 灵敏的
  • genome 基因组
  • following 追踪