Influence of Ethanol on Darunavir Hepatic Clearance and Intracellular PK/PD in HIV-Infected Monocytes, and CYP3A4-Darunavir Interactions Using Inhibition and in Silico Binding Studies
作者: Narasimha M. MiddeYuqing GongTheodore J. CoryJunhao LiBernd MeibohmWeihua LiSantosh Kumar
作者单位: 1University of Tennessee Health Science Center
2University of Tennessee Health Science Center,
3East China University of Science and Technology,
刊名: Pharmaceutical Research, 2017, Vol.34 (9), pp.1925-1933
来源数据库: Springer Journal
DOI: 10.1007/s11095-017-2203-6
关键词: Antiretroviral therapyCytochrome P450Drug-drug interactionEthanolHIV
英文摘要: Although the prevalence of alcohol consumption is higher in HIV+ people than general public, limited information is available on how alcohol affects the metabolism and bioavailability of darunavir (DRV).
原始语种摘要: Although the prevalence of alcohol consumption is higher in HIV+ people than general public, limited information is available on how alcohol affects the metabolism and bioavailability of darunavir (DRV).
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:4.742 (2012)

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关键词翻译
关键词翻译
  • HIV Hydraulic Isolation Valve
  • alcohol 
  • consumption 消耗
  • metabolism 代谢
  • interaction 相互酌
  • available 可供应的
  • general 普遍的
  • information 报告
  • higher 
  • people 民族