Simultaneous Determination of 20 Antibiotics in Bovine Colostrum Tablet Using UHPLC–MS/MS and SPE
作者: Jia ZhengCunxian XiGuomin WangShurui CaoBobin TangZhaode Mu
作者单位: 1College of Pharmacy, Chongqing Medical University
2Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology
3Chongqing Entry-Exit Inspection and Quarantine Bureau
4Chongqing Engineering Technology Research Center of Import and Export Food Safety
刊名: Chromatographia, 2018, Vol.81 (6), pp.947-957
来源数据库: Springer Journal
DOI: 10.1007/s10337-018-3515-3
关键词: UHPLC–MS/MSSPEAntibioticsBovine colostrum tablet
英文摘要: Abstract(#br)A rapid and simple method was developed for the simultaneous determination of 20 antibiotics in bovine colostrum tablets using ultra-high-performance liquid chromatography–tandem mass spectrometry. The samples were prepared by a two-step extraction procedure followed by loading onto a reversed phase HLB cartridge for purification. The matrix-matched standard curves were used to compensate the matrix effects. Linearity was achieved for the analytes in the concentration ranges studied. The limits of detection (LODs) and limits of quantification (LOQs) for all samples were 0.05–2.03 and 0.16–6.78 μg kg −1 , respectively. The mean recoveries were from 81.3 to 113.9% at three spiked levels, the relative standard deviations (RSDs, n = 6) ranged from 0.5 to 12.6%. The developed...
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影响因子:1.437 (2012)

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