Hemorrhage promotes inflammation and myocardial damage following acute myocardial infarction: insights from a novel preclinical model and cardiovascular magnetic resonance
| 作者： | Nilesh R. Ghugre, Mihaela Pop, Reuben Thomas, Susan Newbigging, Xiuling Qi, Jennifer Barry, Bradley H. Strauss, Graham A. Wright |
| 作者单位： |
1Physical Sciences Platform, Sunnybrook Research Institute 2University of Toronto 3Schulich Heart Research Program, Sunnybrook Health Sciences Centre 4Mount Sinai Hospital |
| 刊名： | Journal of Cardiovascular Magnetic Resonance, 2017, Vol.19 (1) |
| 来源数据库： | Springer Nature Journal |
| DOI： | 10.1186/s12968-017-0361-7 |
| 关键词： | Myocardial infarction; Hemorrhage; Inflammation; Microvascular obstruction; T2; T2*; Ischemia reperfusion injury; Cardiovascular magnetic resonance; |
| 英文摘要： | Myocardial hemorrhage is a frequent complication following reperfusion in acute myocardial infarction and is predictive of adverse outcomes. However, it remains unsettled whether hemorrhage is simply a marker of a severe initial ischemic insult or directly contributes to downstream myocardial damage. Our objective was to evaluate the contribution of hemorrhage towards inflammation, microvascular obstruction and infarct size in a novel porcine model of hemorrhagic myocardial infarction using cardiovascular magnetic resonance (CMR). |
| 原始语种摘要： | Myocardial hemorrhage is a frequent complication following reperfusion in acute myocardial infarction and is predictive of adverse outcomes. However, it remains unsettled whether hemorrhage is simply a marker of a severe initial ischemic insult or directly contributes to downstream myocardial damage. Our objective was to evaluate the contribution of hemorrhage towards inflammation, microvascular obstruction and infarct size in a novel porcine model of hemorrhagic myocardial infarction using cardiovascular magnetic resonance (CMR). |
