Hemorrhage promotes inflammation and myocardial damage following acute myocardial infarction: insights from a novel preclinical model and cardiovascular magnetic resonance
作者: Nilesh R. GhugreMihaela PopReuben ThomasSusan NewbiggingXiuling QiJennifer BarryBradley H. StraussGraham A. Wright
作者单位: 1Physical Sciences Platform, Sunnybrook Research Institute
2University of Toronto
3Schulich Heart Research Program, Sunnybrook Health Sciences Centre
4Mount Sinai Hospital
刊名: Journal of Cardiovascular Magnetic Resonance, 2017, Vol.19 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12968-017-0361-7
关键词: Myocardial infarctionHemorrhageInflammationMicrovascular obstructionT2T2*Ischemia reperfusion injuryCardiovascular magnetic resonance
英文摘要: Myocardial hemorrhage is a frequent complication following reperfusion in acute myocardial infarction and is predictive of adverse outcomes. However, it remains unsettled whether hemorrhage is simply a marker of a severe initial ischemic insult or directly contributes to downstream myocardial damage. Our objective was to evaluate the contribution of hemorrhage towards inflammation, microvascular obstruction and infarct size in a novel porcine model of hemorrhagic myocardial infarction using cardiovascular magnetic resonance (CMR).
原始语种摘要: Myocardial hemorrhage is a frequent complication following reperfusion in acute myocardial infarction and is predictive of adverse outcomes. However, it remains unsettled whether hemorrhage is simply a marker of a severe initial ischemic insult or directly contributes to downstream myocardial damage. Our objective was to evaluate the contribution of hemorrhage towards inflammation, microvascular obstruction and infarct size in a novel porcine model of hemorrhagic myocardial infarction using cardiovascular magnetic resonance (CMR).
全文获取路径: Springer  (合作)
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影响因子:4.435 (2012)

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关键词翻译
关键词翻译
  • myocardial 心肌的
  • infarction 梗塞
  • resonance 共振
  • inflammation 炎症
  • acute 急尖的
  • obstruction 塞住
  • preclinical 临证前期的
  • magnetic 磁的
  • cardiovascular 心血管的
  • hemorrhage 出血