Endothelial microparticles are increased in congenital heart diseases and contribute to endothelial dysfunction
作者: Ze-Bang LinHong-Bo CiYan LiTian-Pu ChengDong-Hong LiuYan-Sheng WangJun XuHao-Xiang YuanHua-Ming LiJing ChenLi ZhouZhi-Ping WangXi ZhangZhi-Jun OuJing-Song Ou
作者单位: 1The First Affiliated Hospital of Sun Yat-sen University
2The Key Laboratory of Assisted Circulation, Ministry of Health
3National and Guangdong Province Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases
4State Key Laboratory of Respiratory Dis
刊名: Journal of Translational Medicine, 2017, Vol.15 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12967-016-1087-2
关键词: Endothelial microparticlesCongenital heart diseaseInflammationEndothelial nitric oxide synthaseP38 MAPK pathway
英文摘要: We previously demonstrated that endothelial microparticles (EMPs) are increased in mitral valve diseases and impair valvular endothelial cell function. Perioperative systemic inflammation is an important risk factor and complication of cardiac surgery. In this study, we investigate whether EMPs increase in congenital heart diseases to promote inflammation and endothelial dysfunction.
原始语种摘要: We previously demonstrated that endothelial microparticles (EMPs) are increased in mitral valve diseases and impair valvular endothelial cell function. Perioperative systemic inflammation is an important risk factor and complication of cardiac surgery. In this study, we investigate whether EMPs increase in congenital heart diseases to promote inflammation and endothelial dysfunction.
全文获取路径: Springer  (合作)
分享到:
来源刊物:
影响因子:3.459 (2012)

×
关键词翻译
关键词翻译
  • congenital 先天的
  • contribute 贡献
  • increased 增加
  • heart 心脏
  • inflammation 炎症
  • dysfunction 功能障碍
  • demonstrated 探明的储量
  • previously 以前
  • pathway 轨道
  • valvular 壳瓣的