Metabolic network model guided engineering ethylmalonyl-CoA pathway to improve ascomycin production in Streptomyces hygroscopicus var. ascomyceticus
作者: Junhua WangCheng WangKejing SongJianping Wen
作者单位: 1Key Laboratory of System Bioengineering (Tianjin University), Ministry of Education
2Tianjin University
刊名: Microbial Cell Factories, 2017, Vol.16 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12934-017-0787-5
关键词: AscomycinFK520Metabolic network modelEthylmalonyl-CoA pathwayStreptomyces hygroscopicus var. ascomyceticus
英文摘要: Ascomycin is a 23-membered polyketide macrolide with high immunosuppressant and antifungal activity. As the lower production in bio-fermentation, global metabolic analysis is required to further explore its biosynthetic network and determine the key limiting steps for rationally engineering. To achieve this goal, an engineering approach guided by a metabolic network model was implemented to better understand ascomycin biosynthesis and improve its production.
原始语种摘要: Ascomycin is a 23-membered polyketide macrolide with high immunosuppressant and antifungal activity. As the lower production in bio-fermentation, global metabolic analysis is required to further explore its biosynthetic network and determine the key limiting steps for rationally engineering. To achieve this goal, an engineering approach guided by a metabolic network model was implemented to better understand ascomycin biosynthesis and improve its production.
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:3.306 (2012)

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关键词翻译
关键词翻译
  • ascomycin 子囊霉素
  • engineering 工程
  • pathway 轨道
  • CoA 辅酶 A
  • improve 改进
  • network 网络
  • production 生产
  • guided 制导的
  • metabolic 新陈代谢的
  • macrolide 大环内脂