Mechanisms of hormone resistance in breast cancer
作者: Kathryn B. Horwitz
作者单位: 1Department of Medicine, University of Colorado Health Sciences Center
刊名: Breast Cancer Research and Treatment, 1993, Vol.26 (2), pp.119-130
来源数据库: Springer Nature Journal
DOI: 10.1007/BF00689685
关键词: antiestrogensendocrine therapyestrogen receptorprogesterone receptorresistancesplicingtamoxifenvariant receptors
原始语种摘要: Summary(#br)At least half of all advanced breast cancers are positive for estrogen receptor (ER) and progesterone receptor (PR), but many nevertheless fail to respond to endocrine therapy. Studies of breast cancer cell lines and breast tumor specimens are beginning to reveal molecular heterogeneity of the receptors in subpopulations of these cells, leading to altered receptor function and sometimes to hormone resistance. Here we will review the data on molecular and cellular heterogeneity involving ER and PR, and possible underlying mechanisms of resistance to tamoxifen and progestins.
全文获取路径: Springer Nature  (合作)
影响因子:4.469 (2012)

  • breast 胸部
  • hormone 激素
  • cancer 癌症
  • resistance 抵抗