Progesterone Receptors A and B Differentially Affect the Growth of Estrogen-Dependent Human Breast Tumor Xenografts
作者: Carol A. SartoriusTianjie ShenKathryn B. Horwitz
作者单位: 1Department of Medicine, University of Colorado Health Sciences Center
2Department of Pathology, University of Colorado Health Sciences Center
刊名: Breast Cancer Research and Treatment, 2003, Vol.79 (3), pp.287-299
来源数据库: Springer Nature Journal
DOI: 10.1023/A:1024031731269
关键词: breast cancersestrogensligand-independenceprogesterone receptorsxenografts
英文摘要: Abstract(#br)Sixty to seventy percent of all primary human breast cancers are estrogen-dependent and express both estrogen (ER) and progesterone receptors (PR). Whereas expression of the two naturally occurring PR isoforms, PR-A and PR-B, is close to equimolar in normal human tissues, the ratio of the two receptors varies extensively in tumors. This is important since the two PR are functionally distinct and have differential repressor effects on ER. The PR isoform content may, therefore, affect the outcome of endocrine therapies targeted at ER. Study of PR isoforms is difficult because the two receptors are co-expressed in cells under estradiol stimulation. We have engineered four sets of T47D human breast cancer cells that, independent of estrogen: (i) express only PR-A; (ii) express...
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影响因子:4.469 (2012)

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  • Growth 生长