Double-gating mechanism and diversity of an adenosine triphosphate (ATP)-sensitive K + channel in neurons acutely dissociated from rat neocortex
作者: Zhenqing TongXiangdong TangWenjun Yang
作者单位: 1Department of Physiology, First Military Medical University
2Department of Neurology, Nanfang Hospital
刊名: Science in China Series C: Life Sciences, 1997, Vol.40 (1), pp.10-17
来源数据库: Springer Nature Journal
DOI: 10.1007/BF02879102
关键词: ATP-sensitive K + channelgating kineticspatch clampdissociated neuronrat
原始语种摘要: Abstract(#br)Classically, ion channels are classified into 2 groups: chemical-sensitive (ligand-gated) and voltage sensitive channels. Single ATP-sensitive K + (K-ATP) channel currents were recorded in acutely dissociated rat neocortical neurons using patch clamp technique. A type of K-ATP channel has been found to be gated not only by intracellular ATP, but also by membrane potential (V m ), and proved to be a novel mechanism underlying the gating of ion channels, namely bi-gating mechanism. The results also show that the K-ATP channels possess heterogeneity and diversity. These types of K-ATP channels have been identified in 40.12% of all patches, which are different in activation-threshold and voltage-sensitivity. The present experiment studied the type-3 K-ATP channel with a unitary...
全文获取路径: Springer Nature  (合作)
影响因子:1.61 (2011)

  • dissociated 离解的
  • neocortex 新皮质
  • triphosphate 三磷酸盐
  • gating 浇注系统
  • acutely 尖锐地
  • adenosine 腺苷
  • ATP Acceptance Test Procedure
  • mechanism 机构
  • channel 槽水道
  • diversity 差异