Differential effects of nitric oxide on rod and cone pathways in carp retina
作者: Bing YeJiulin DuXiongli Yang
作者单位: 1Shanghai Institute of Physiology and Shanghai Joint Laboratory of Life Science, Chinese Academy of Sciences
刊名: Science in China Series C: Life Sciences, 1997, Vol.40 (1), pp.71-78
来源数据库: Springer Nature Journal
DOI: 10.1007/BF02879109
关键词: nitric oxiderod pathwaycone pathwayelectroretinogram (ERG)horizontal cell
英文摘要: Abstract(#br)The effects of nitric oxide (NO) on electroretinograms and light responses of horizontal cells intracellularly recorded from isolated, superfused carp retinas were studied. Sodium nitroprusside (SNP), an NO donor, suppressed scotopic b wave, while enhancing photopic b wave, and the effects could be blocked by hemoglobin, an NO chelator. Furthermore, following SNP application, light responses of rod horizontal cells were reduced in size and those of cone horizontal cells were increased. These results suggest that NO suppresses the activity of rod pathway, but enhances that of cone pathway in the outer retina. Moreover, the effects of methylene blue, an inhibitor of soluble guanylate cyclase, on rod and cone horizontal cells were just opposite to those of SNP, implying that the...
全文获取路径: Springer Nature  (合作)
影响因子:1.61 (2011)

  • retina 视网膜
  • nitric 氮的
  • oxide 氧化物
  • effects 海员自身物品