Role of intracellular sodium activity in the control of contraction in cardiac purkinje fibers
作者: P. AbeteM. Vassalle
作者单位: 1Department of Physiology, SUNY, HSC
刊名: Journal of Biomedical Science, 1994, Vol.1 (1), pp.28-42
来源数据库: Springer Nature Journal
DOI: 10.1007/BF02258337
关键词: NorepinephrineHigh [Ca] oStrophanthidinNa/K pumpNa/Ca exchange
原始语种摘要: Abstract(#br)The role of intracellular sodium activity (a Na i ) in the control of force was studied in sheep cardiac Purkinje fibers exposed to norepinephrine (NE) and high [Ca] o in the absence and presence of overdrive or of a low concentration of strophanthidin. Both NE and high [Ca] o decrease a Na i and increase force, while overdrive increases and low strophanthidin decreases both parameters. In the presence of NE, overdrive increases a Na i less than force and is followed by a more pronounced undershoot in a Na i and force. In contrast, in high [Ca] o overdrive increases a Na i more than force and is followed by a less pronounced undershoot in a Na i and force than in NE. High [Ca] o increases force to a peak, but then the decreasing a Na i reduces force. In all these conditions,...
全文获取路径: Springer Nature  (合作)
影响因子:2.458 (2012)

  • sodium 
  • activity 活度
  • control 控制
  • intracellular 胞内的
  • contraction 收缩
  • cardiac 贲门