EDRF(NO)-mediated modulation of collagen-induced platelet accumulation in rat pulmonary microcirculation
作者: P. J. S. ChiuG. Tetzloff
作者单位: 1Department of Pharmacology (2600), Schering-Plough Research Institute
刊名: Journal of Biomedical Science, 1994, Vol.1 (1), pp.43-48
来源数据库: Springer Nature Journal
DOI: 10.1007/BF02258338
关键词: Endothelium-derived relaxing factorNitric oxidePlatelets111 Indium oxineCyclic GMPZaprinast
英文摘要: Abstract(#br)Endothelium-derived relaxing factor (EDRF) or nitric oxide (NO) biosynthesis from L -arginine occurs in the endothelium and platelets and may modulate plate-let function and contribute to thromboresistance in the vessel wall. A rat model was used to evaluate selective accumulation of 111 In-labeled platelets in the pulmonary microcirculation following the administration of collagen, adenosine 5′-diphosphate (ADP) or thrombin. Platelet aggregation was monitored continuously over the thorax using a microcomputer-based system. Sodium nitroprusside, a stimulator of soluble guanylate cyclase and zaprinast, a phosphodiesterase V inhibitor, both known to cause accumulation of cyclic guanosine monophosphate, exhibited moderate inhibitory activity, which was shared by L -arginine. N G...
全文获取路径: Springer Nature  (合作)
影响因子:2.458 (2012)

  • EDRF 内皮细胞舒血管因子
  • NO Normally Open
  • collagen 胶骨硬蛋白质
  • platelet 血小板
  • induced 感应的
  • pulmonary 肺的
  • accumulation 堆积
  • modulation