Oncogenes, protein tyrosine kinases, and signal transduction
作者: Delong LiuLu-Hai Wang
作者单位: 1Department of Microbiology, The Mount Sinai School of Medicine
刊名: Journal of Biomedical Science, 1994, Vol.1 (2), pp.65-82
来源数据库: Springer Nature Journal
DOI: 10.1007/BF02257980
关键词: Growth factorLigandOncogenesisPhosphotyrosineReceptor
英文摘要: Abstract(#br)Many oncogenes encode protein tyrosine kinases (PTKs). Oncogenic mutations of these genes invariably result in constitutive activation of these PTKs. Autophosphorylation of the PTKs and tyrosine phosphorylation of their cellular substrates are essential events for transmission of the mitogenic signal into cells. The recent discovery of the characteristic amino acid sequences, of the src homology domains 2 and 3 (SH2 and SH3), and extensive studies on proteins containing the SH2 and SH3 domains have revealed that protein tyrosine-phosphorylation of PTKs provides phosphotyrosine sites for SH2 binding and allows extracellular signals to be relayed into the nucleus through a chain of protein-protein interactions mediated by the SH2 and SH3 domains. Studies on oncogenes, PTKs and...
全文获取路径: Springer Nature  (合作)
影响因子:2.458 (2012)

  • transduction 转导
  • protein 蛋白质
  • tyrosine 酪氨酸
  • signal 信号