Adrenergic modulation of potassium currents in isolated human atrial myocytes
作者: Ming-Jai SuJo-Feng ChiShu-Hsun Chu
作者单位: 1Department of Surgery, College of Medicine, National Taiwan University
2Pharmacological Institute College of Medicine, National Taiwan University
刊名: Journal of Biomedical Science, 1994, Vol.1 (3), pp.193-200
来源数据库: Springer Nature Journal
DOI: 10.1007/BF02253349
关键词: Human atrial myocytesPotassium currentsAdrenergic modulationPhenylephrineIsoproterenol
英文摘要: Abstract(#br)The adrenergic modulation of inwardly rectifying and depolarization-activated outward potassium currents was studied in single cardiac myocytes obtained from the human atrium. Membrane currents were recorded in enzymatically dissociated cells using the whole-cell voltage-clamp technique. It was observed that, in the presence or absence of atenolol (or 1 µ M propranolol), 30 µ M phenylephrine attenuated inwardly rectifying and depolarization-activated outward potassium currents including both transient and late-activated current. This suppressant effect of phenylephrine could be prevented by pretreatment with an α-adrenoceptor antagonist. Isoproterenol (30 µ M ) increased the late outward potassium current and net transient outward current. It is concluded that, in human...
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影响因子:2.458 (2012)

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关键词翻译
关键词翻译
  • atrial 围鳃的
  • potassium 
  • modulation 
  • human 人的
  • isolated 隔离