Renal eicosanoids and blood pressure in genetically hypertensive rats of the lyon strain
作者: Jean SassardDaniel Benzoni
作者单位: 1Department of Physiology and Clinical Pharmacology, URA CNRS 1483, Faculty of Pharmacy
刊名: Journal of Biomedical Science, 1994, Vol.1 (4), pp.201-203
来源数据库: Springer Nature Journal
DOI: 10.1007/BF02253302
关键词: HypertensionEicosanoidRatGeneticsKidney
英文摘要: Abstract(#br)The present paper reviews the evidence for a possible involvement of renal eicosanoids in the pathophysiology of high blood pressure in genetically hypertensive rats of the Lyon strain. Both in vivo and in vitro experiments suggest that an increased ability to synthesize the vasoconstrictor prostaglandin H 2 and/or thromboxane A 2 in renal vessels (1) acts as an autocrine amplifier of pressor agents and (2) may contribute to resetting the pressure natriuresis curve which is a prerequisite for the development and maintenance of hypertension.
全文获取路径: Springer Nature  (合作)
影响因子:2.458 (2012)

  • hypertensive 高血压的
  • pressure 压力
  • blood 血液
  • strain 应变