Abnormalities of tumor suppressor gene p16 in pancreatic carcinoma: immunohistochemical and genetic findings compared with clinicopathological parameters
作者: Koushiro OhtsuboHiroyuki WatanabeYasushi YamaguchiYu-Xin HuYoshiharu MotooTakashi OkaiNorio Sawabu
作者单位: 1Department of Internal Medicine and Medical Oncology, Cancer Research Institute, Kanazawa University
刊名: Journal of Gastroenterology, 2003, Vol.38 (7), pp.663-671
来源数据库: Springer Nature Journal
DOI: 10.1007/s00535-003-1119-6
关键词: p16pancreatic carcinomaimmunohistochemical stainingmutationhypermethylation
英文摘要: Background . Abnormalities of the tumor suppressor gene p16 have been reported in a variety of human tumors but are rare in pancreatic carcinoma except for cancer cell lines and xenografts. Their clinicopathological significance remains unknown. The purpose of this study was to examine immunohistochemical and genetic alterations of p16 in primary pancreatic carcinoma tissues and to investigate the relation between abnormalities of p16 and clinicopathological parameters to elucidate their clinicopathological significance. Methods . We investigated p16 expression in 60 pancreatic carcinoma cases by immunohistochemistry using a monoclonal antibody clone G175-405. In addition, we analyzed genetic alterations of the p16 gene using DNA extracted from microdissected tissue of pancreatic...
全文获取路径: Springer Nature  (合作)
影响因子:3.788 (2012)

  • pancreatic 胰的
  • findings 结论
  • carcinoma 癌症
  • suppressor 抑制栅
  • compared 肿瘤和正常组织细胞周期的比较
  • tumor 肿胀
  • parameters 参数
  • genetic 遗传的