RETRACTED ARTICLE: Determination of sulpha drugs and ascorbic acid, individually or in mixture, with N -chlorosuccinimide
作者: Ashutosh SrivastavaRenuka AbbiAnita GuptaSusmeet BindraSunil K. Singh
作者单位: 1Department of Chemistry, University of Jabalpur
2Department of Chemistry, University of Pittsburgh
刊名: Microchimica Acta, 1989, Vol.99 (1-2), pp.81-89
来源数据库: Springer Nature Journal
DOI: 10.1007/BF01242793
关键词: spectrophotometrictitrimetricsulfa drugsvitamin-CN -chlorosuccinimide
英文摘要: Abstract(#br)New spectrophotometric and titrimetric methods for the determination of sulphonamides with N -chlorosuccinimide (NCS) were developed. The spectrophotometric measurements can be made at 324–395 nm at pH 7.4 at room temperature, the stoichiometry being 1: 2, ( p -H 2 N-C 6 H 4 -SO 2 NHR): (NCS) forming a dibromination product in presence of acidified potassium bromide. Potentiometrically or visually using methyl red as indicator, sulphonamides are titrated in pharmaceutical preparations by NCS always in presence of acidified potassium bromide. Ascorbic acid is determined alone and also in combinations, by first titrating it using potassium iodide and starch or 2,6-dichlorophenolindophenol as indicator. Acylation or diazotization of the aromatic amino groups that prevents...
全文获取路径: Springer Nature  (合作)
影响因子:3.434 (2012)

  • sulpha 磺胺
  • drugs 药品
  • mixture 混合物