Investigations on the Decomposition of Carboplatin in Infusion Solutions II. Effect of 1,1-Cyclobutanedicarboxylic Acid Admixture
作者: B. SchnurrH. HeinrichR. Gust
作者单位: 1Institut für Pharmazie der Freien Universität Berlin, Königin-Luise Str. 2 + 4, D-14195 Berlin, Germany
刊名: Microchimica Acta, 2002, Vol.140 (1-2), pp.141-148
来源数据库: Springer Nature Journal
DOI: 10.1007/s00604-002-0898-4
关键词: Key words: Carboplatininfusion solutionsHPLC.
英文摘要: Abstract.(#br) Eleven infusion solutions containing carboplatin ( ≈ 10 mg/ml) stored for 5 to 78 months at room temperature were investigated for the content of carboplatin and the profile of decomposition products by means of atomic absorption spectrophotometry (AAS) and high performance liquid chromatography (HPLC). Carboplatin loss was between 3.09% and 7.28%. Carboplatin degradation was exponential and depended only on the time of storage. For seven of the investigated products an admixture of 1,1-cyclobutane-dicarboxylic acid (CBDCA) (0.75%–2%) was shown. This admixture did not suppress the break-down of carboplatin, but changed the quantity of certain degradation products. Besides hydrophilic aqua- or hydroxyplatinum(II)-species also hydrophobic side products were detectable....
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影响因子:3.434 (2012)

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