Expression patterns of transcription factors in progressively transformed germinal centers and Hodgkin lymphoma
作者: Susanne Steimle-GrauerMarianne TinguelyLaila SeadaChristian FellbaumMartin-Leo Hansmann
作者单位: 1Senckenbergisches Institute of Pathology, Johann Wolfgang Goethe-University of Frankfurt, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany
刊名: Virchows Archiv, 2003, Vol.442 (3), pp.284-293
来源数据库: Springer Nature Journal
DOI: 10.1007/s00428-002-0735-5
关键词: Hodgkin lymphoma Transcription factors BSAP/Pax5 Oct2 BOB.1/OBF1 MUM1/IRF4
原始语种摘要: Abstract.(#br) The World Health Organization (WHO) classification of Hodgkin lymphoma (HL) distinguishes two types: Classical Hodgkin lymphoma (CHL) and nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). Both groups have in common that they mostly derive from B cells with rare classical cases originating from T cells. They differ in their histomorphology, immunophenotype, and clinical behavior. One of the subtypes of CHL, designated as lymphocyte-rich classical Hodgkin lymphoma (LRCHL), shares some morphological features with NLPHL. The transcription factors BSAP, BOB.1, Oct2 and MUM1 are sequentially expressed in normal B-cell development. In order to investigate the relationship between the CHL subgroups and NLPHL, we examined the protein expression of these transcription factors...
全文获取路径: Springer Nature  (合作)
影响因子:2.676 (2012)

  • germinal 胚的
  • lymphoma 淋巴瘤
  • progressively 前进地
  • transcription 地名转写
  • centers 机组间距