Characterization of immunoglobulin G-Fe receptor activity in the outflow system of the cerebrospinal fluid
作者: Jon SiegelmanHoward B. FleitNancy S. Peress
作者单位: 1Department of Pathology, Veterans Administration Medical Center
2Department of Pathology, State University of New York
3Department of Neurobiology and Behavior, State University of New York
4Department of Pathology, University Hospita, SUNY
刊名: Cell and Tissue Research, 1987, Vol.248 (3), pp.599-605
来源数据库: Springer Nature Journal
DOI: 10.1007/BF00216489
关键词: ArachnoidFc receptorIg-oligomersImmunoglobulinsMonoclonal antibodyPiaHumanRabbit
英文摘要: Summary(#br)We have examined IgG Fc receptor (FcR) activity of human and rabbit arachnoid granulations and leptomeninges using antibody (IgG)-coated erythrocytes (EIgG), covalently crosslinked IgG dimers, trimers and oligomers, immune complexes, aggregated Fc fragments and a monoclonal anti-human neutrophil Fc receptor antibody, 3G8. EIgG bound specifically to cells of the leptomeninges and arachnoid granulations; uncoated erythrocytes, F(ab′) 2 -coated, or IgM-coated erythrocytes failed to bind. The specificity of this interaction was demonstrated by inhibition studies. Monomeric IgG and Fc fragments blocked EIgG adherence, whereas bovine serum albumin (BSA), Fab fragments of IgG and the monoclonal anti-neutrophil FcR antibody failed to inhibit EIgG adherence. Monomeric IgG inhibited FcR...
全文获取路径: Springer Nature  (合作)
影响因子:3.677 (2012)

  • immunoglobulin 免疫球蛋白
  • receptor 接受体
  • cerebrospinal 脑脊髓的
  • outflow 
  • activity 活度
  • fluid 
  • system