Intensive pulse therapies for focal glomerulosclerosis in South African children
作者: Miriam AdhikariRajendra BhimmaHoosen M. Coovadia
作者单位: 1Department of Paediatrics and Child Health, University of Natal, Faculty of Medicine, PO Box 17039, Congella, 4013, South Africa
刊名: Pediatric Nephrology, 1997, Vol.11 (4), pp.423-428
来源数据库: Springer Nature Journal
DOI: 10.1007/s004670050309
关键词: Key words: Focal segmental glomerulosclerosisPulse cyclophosphamideMethylprednisoloneOral prednisone
原始语种摘要: Abstract.(#br) Seven children with steroid-resistant focal segmental glomerulosclerosis (SR-FGS) were placed on a therapeutic protocol of methylprednisolone (MP), oral prednisone (pred) and oral cyclophosphamide (CYC) given over 16 months (regimen A). Another 5 children with SR-FGS were treated with a shorter course of intravenous CYC (monthly doses over 6 months), intravenous MP (3 consecutive daily doses) and oral pred 2 mg/kg (alternate days) (regimen B). With regimen A, 1 child had a short remission, and in the others, oedema subsided, the urine protein/creatinine ratio decreased, haematuria disappeared and the estimated glomerular filtration rate (GFR) increased. The observation period was 21 – 42 months and the drugs were well tolerated. With regimen B, 2 patients went into complete...
全文获取路径: Springer Nature  (合作)
影响因子:2.939 (2012)

  • focal 焦点的
  • African 非洲的
  • children 子女
  • pulse 脉冲