The role of p53 as a surrogate marker for chemotherapeutical responsiveness in ovarian cancer
作者: Dirk O. BauerschlagChristian SchemMarion T. WeigelConstantin KaisenbergAlexander StraussThomas BauknechtNicolai MaassIvo Meinhold-Heerlein
作者单位: 1Department of Gynecology and Obstetrics University Hospital, Universitätsklinikum RWTH Aachen
2Department of Gynecology and Obstetrics University Hospital, Universitätsklinikum Schleswig-Holstein
3Department of Gynecology and Obstetrics University Hospital, Medizinische Hochschule Hannover
4Lilly Deutschland
刊名: Journal of Cancer Research and Clinical Oncology, 2010, Vol.136 (1), pp.79-88
来源数据库: Springer Nature Journal
DOI: 10.1007/s00432-009-0639-8
关键词: Ovarian cancerp53Mutational analysisChemotherapeutical responsiveness
英文摘要: Abstract(#br) Introduction(#br)In advanced ovarian cancers (OCs), p53 mutations are frequently observed. The objective of this study was to explore the value of the p53 mutational status, using four different techniques, in advanced OC patients as a predictive marker for responsiveness to platinum-based chemotherapy.(#br) Methods(#br)One hundred and four, mostly serous papillary OC specimens were analyzed, of which all received a platinum containing chemotherapy after optimal cyto-reductive surgery. To verify the p53 mutational status, immunohistochemical staining with monoclonal antibodies, functional yeast assay (FASAY), single-strand conformation polymorphism analysis (SSCP) and genomic sequencing was performed in parallel.(#br) Results(#br)Out of ten OC patients [2 low malignant...
全文获取路径: Springer Nature  (合作)
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关键词翻译
关键词翻译
  • responsiveness 应答性
  • surrogate 代替
  • ovarian 卵巢的
  • marker 标试器
  • cancer 癌症