Evaluation and comparison of computational tools for RNA-seq isoform quantification
作者: Chi ZhangBaohong ZhangLih-Ling LinShanrong Zhao
作者单位: 1Early Clinical Development, Pfizer Worldwide R&D
2Inflammation and Immunology RU, Pfizer Worldwide R&D
刊名: BMC Genomics, 2017, Vol.18 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12864-017-4002-1
关键词: RNA-seqQuantificationIsoformData analysisRSEMSalmonSalfishKallisto
英文摘要: Alternatively spliced transcript isoforms are commonly observed in higher eukaryotes. The expression levels of these isoforms are key for understanding normal functions in healthy tissues and the progression of disease states. However, accurate quantification of expression at the transcript level is limited with current RNA-seq technologies because of, for example, limited read length and the cost of deep sequencing.
原始语种摘要: Alternatively spliced transcript isoforms are commonly observed in higher eukaryotes. The expression levels of these isoforms are key for understanding normal functions in healthy tissues and the progression of disease states. However, accurate quantification of expression at the transcript level is limited with current RNA-seq technologies because of, for example, limited read length and the cost of deep sequencing.
全文获取路径: Springer Nature  (合作)
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影响因子:4.397 (2012)

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关键词翻译
关键词翻译
  • quantification 量化
  • RNA ROYAL NEPAL AIRLINES CORP.
  • expression 表示
  • transcript 转录产物
  • sequencing 排序
  • observed 观察到的
  • computational 计算的
  • length 距离
  • understanding 理解
  • higher