Tumour suppressor EP300, a modulator of paclitaxel resistance and stemness, is downregulated in metaplastic breast cancer
作者: Muhammad AsaduzzamanStephanie ConstantinouHaoxiang MinJohn GallonMeng-Lay LinPoonam SinghSelina RaguzSimak AliSami ShoushaR. Charles CoombesEric W.-F. LamYunhui HuErnesto Yagüe
作者单位: 1Hammersmith Hospital Campus
2University of Dhaka
3Hutchison/MRC Research Centre
4Charing Cross Hospital
5Tianjin Medical University Cancer Institute and Hospital
刊名: Breast Cancer Research and Treatment, 2017, Vol.163 (3), pp.461-474
来源数据库: Springer Nature Journal
DOI: 10.1007/s10549-017-4202-z
关键词: MetastasisCancer stem cellsDrug resistanceBCL2ABCG2EP300 signature
英文摘要: We have previously described a novel pathway controlling drug resistance, epithelial-to-mesenchymal transition (EMT) and stemness in breast cancer cells. Upstream in the pathway, three miRs (miR-106b, miR-93 and miR-25) target EP300, a transcriptional activator of E-cadherin. Upregulation of these miRs leads to the downregulation of EP300 and E-cadherin with initiation of an EMT. However, miRs regulate the expression of many genes, and the contribution to EMT by miR targets other than EP300 cannot be ruled out.
原始语种摘要: We have previously described a novel pathway controlling drug resistance, epithelial-to-mesenchymal transition (EMT) and stemness in breast cancer cells. Upstream in the pathway, three miRs (miR-106b, miR-93 and miR-25) target EP300, a transcriptional activator of E-cadherin. Upregulation of these miRs leads to the downregulation of EP300 and E-cadherin with initiation of an EMT. However, miRs regulate the expression of many genes, and the contribution to EMT by miR targets other than EP300 cannot be ruled out.
全文获取路径: Springer Nature  (合作)
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影响因子:4.469 (2012)

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关键词翻译
关键词翻译
  • breast 胸部
  • metaplastic 化生
  • suppressor 抑制栅
  • EMT EMergency Treatment
  • cancer 癌症
  • pathway 轨道
  • mesenchymal 间叶细胞的
  • initiation 创始
  • regulate 控制
  • transition 转移