A randomized phase II trial of ridaforolimus, dalotuzumab, and exemestane compared with ridaforolimus and exemestane in patients with advanced breast cancer
作者: Hope S. RugoOlivier TrédanJungsil RoSerafin M. MoralesMario CamponeAntonino MusolinoNoémia AfonsoMarta FerreiraKyong Hwa ParkJavier CortesAntoinette R. TanJoanne L. BlumLamar EatonChristine K. GauseZhen WangEllie ImDavid J. MauroMary Beth JonesAndrew DenkerJosé Baselga
作者单位: 1UCSF Helen, Diller Family Comprehensive Cancer Center
2Centre Léon Bérard
3National Cancer Center
4H. de Lleida Arnau de Vilanova
5Institut de Cancérologie de l’Ouest
6University Hospital of Parma
7Instituto Português de Oncologia Francisco Gentil
8Korea University Medical Center
9Madrid and Vall d´Hebron Institute of Oncology (VHIO)
10Rutgers Cancer Institute of New Jersey
11Carolinas HealthCare System
12Texas Oncology, US Oncology
13Merck& Co., Inc.
14Checkmate Pharmaceuticals
15Alexion Pharmaceuticals
16Memorial Sloan Kettering Cancer Center
刊名: Breast Cancer Research and Treatment, 2017, Vol.165 (3), pp.601-609
来源数据库: Springer Nature Journal
DOI: 10.1007/s10549-017-4375-5
关键词: Breast cancerRidaforolimusMTORDalotuzumabIGF1RExemestane
英文摘要: To evaluate whether adding humanized monoclonal insulin growth factor-1 receptor (IGF-1R) antibody (dalotuzumab) to mammalian target of rapamycin (mTOR) inhibitor (ridaforolimus) plus aromatase inhibitor (exemestane) improves outcomes in patients with estrogen receptor (ER)-positive advanced/metastatic breast cancer.
原始语种摘要: To evaluate whether adding humanized monoclonal insulin growth factor-1 receptor (IGF-1R) antibody (dalotuzumab) to mammalian target of rapamycin (mTOR) inhibitor (ridaforolimus) plus aromatase inhibitor (exemestane) improves outcomes in patients with estrogen receptor (ER)-positive advanced/metastatic breast cancer.
全文获取路径: Springer Nature  (合作)
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影响因子:4.469 (2012)

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关键词翻译
关键词翻译
  • breast 胸部
  • advanced 先进的
  • trial 试验
  • cancer 癌症
  • aromatase 芳香酶
  • compared 肿瘤和正常组织细胞周期的比较
  • humanized 人化的
  • estrogen 雌激素
  • monoclonal 单细胞系的
  • rapamycin 雷帕霉素