Simultaneous analysis of nine aromatic amines in mainstream cigarette smoke using online solid-phase extraction combined with liquid chromatography-tandem mass spectrometry
作者: Jie ZhangRuoshi BaiZhaojuan ZhouXingyu LiuJun Zhou
作者单位: 1Beijing Third Class Tobacco Super vision Station
刊名: Analytical and Bioanalytical Chemistry, 2017, Vol.409 (11), pp.2993-3005
来源数据库: Springer Nature Journal
DOI: 10.1007/s00216-017-0245-6
关键词: Online solid-phase extractionLiquid chromatography-tandem mass spectrometryAromatic aminesMainstream cigarette smoke
原始语种摘要: A fully automated analytical method was developed and validated by this present study. The method was based on two-dimensional (2D) online solid-phase extraction liquid chromatography-tandem mass spectrometry (SPE-LC-MS/MS) to determine nine aromatic amines (AAs) in mainstream smoke (MSS) simultaneously. As a part of validation process, AAs yields for 16 top-selling commercial cigarettes from China market were evaluated by the developed method under both Health Canada Intensive (HCI) and ISO machine smoking regimes. The gas phase of MSS was trapped by 25 mL 0.6 M hydrochloric acid solution, while the particulate phase was collected on a glass fiber filter. Then, the glass fiber pad was extracted with hydrochloric acid solution in an ultrasonic bath. The extract was analyzed with 2D online...
全文获取路径: Springer Nature  (合作)
影响因子:3.659 (2012)

  • extraction 提取
  • chromatography 色层分离法
  • amines 
  • phase 相位
  • liquid 液体
  • toluidine 甲苯胺
  • aromatic 香的
  • tandem 串联机
  • naphthylamine 萘胺
  • spectrometry 光谱测定