Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer
作者: Verena ZuberFrancesco BettellaAree Witoelarthe PRACTICAL Consortiumthe CRUK GWASthe BCAC Consortiumthe TRICL ConsortiumOle A. AndreassenIan G. MillsAlfonso Urbanucci
作者单位: 1Nordic EMBL Partnership, Faculty of Medicine, University of Oslo
2University of Oslo
3Oslo University Hospital
4European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus
5University of Cambridge
6Institute for Cancer Research, Oslo University Hospital
7Queen’s University
刊名: BMC Genomics, 2017, Vol.18 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12864-017-3620-y
关键词: BRD4Genome-wide association studiesSNPsFunctional annotationChromatinRisk lociProstate cancer riskBreast cancer riskSchizophreniaSuper-enhancer
原始语种摘要: Epigenetic information can be used to identify clinically relevant genomic variants single nucleotide polymorphisms (SNPs) of functional importance in cancer development. Super-enhancers are cell-specific DNA elements, acting to determine tissue or cell identity and driving tumor progression. Although previous approaches have been tried to explain risk associated with SNPs in regulatory DNA elements, so far epigenetic readers such as bromodomain containing protein 4 (BRD4) and super-enhancers have not been used to annotate SNPs. In prostate cancer (PC), androgen receptor (AR) binding sites to chromatin have been used to inform functional annotations of SNPs.
全文获取路径: Springer Nature  (合作)
分享到:
来源刊物:
影响因子:4.397 (2012)

×
关键词翻译
关键词翻译
  • functional 功能的
  • tissue 组织
  • nucleotide 核苷酸
  • specific 
  • protein 蛋白质
  • prostate 前列腺
  • chromatin 染色质
  • genomic 染色体组的
  • cancer 癌症
  • annotation 注解